Hybrid Voltage Sensor Imaging from Genetically Targeted Neurons in Hippocampal and 3 Spinal Cord Slices 4 5 6
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چکیده
1 2 Hybrid Voltage Sensor Imaging from Genetically Targeted Neurons in Hippocampal and 3 Spinal Cord Slices 4 5 6 Dongsheng Wang, Tiffany Poon, Shane McMahon, Samuel L. Pfaff, Lea Ziskind7 Conhaim, Baron Chanda, Meyer B. Jackson 8 9 1. Department of Physiology, University of Wisconsin, Madison, WI 53706. 10 2. Howard Hughes Medical Institute and Gene Expression Laboratory, The Salk 11 Institute for Biological Sciences, San Diego, CA 92109. 12 3. Biophysics Ph.D. Program, University of Wisconsin, Madison, WI 53706. 13 Contact information: Meyer Jackson, Dept. Physiology, University of Wisconsin, 14 Madison WI, 53706; [email protected] 15 16 Running head: Voltage imaging from genetically targeted cells 17 18 19 Abstract 20 Genetically encoded optical voltage sensors function well in cultured cells, but 21 their greatest promise, the study of intact neural circuits, remains unfulfilled. Here we 22 tested genetically encoded probes in brain and spinal slices from transgenic mice using 23
منابع مشابه
Innovative Methodology Hybrid voltage sensor imaging of electrical activity from neurons in hippocampal slices from transgenic mice
Wang D, McMahon S, Zhang Z, Jackson MB. Hybrid voltage sensor imaging of electrical activity from neurons in hippocampal slices from transgenic mice. J Neurophysiol 108: 3147–3160, 2012. First published September 19, 2012; doi:10.1152/jn.00722.2012.— Gene targeting with genetically encoded optical voltage sensors brings the methods of voltage imaging to genetically defined neurons and offers a ...
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